Jurgen Klopp opted to leave the Portuguese forward on the bench for the FA Cup semi-final victory over Manchester City, after he picked up a knock in the days leading up to the Wembley trip.
Having rested a number of players for the Champions League win over Benfica last week, Liverpool face another juggling act ahead of two derbies at Anfield that arrive within days of each other.
After United visit on Tuesday, Everton are their next opponents at the weekend before Villarreal head to Merseyside for the first leg of their Champions League semi-final tie.
Therefore Klopp could turn to Joel Matip, Jota, Roberto Firmino or Jordan Henderson after they started the City game on the bench.
The manager said on Monday: “There were some players not in the squad at the weekend and will not be in the squad for tomorrow, even if they are in really good shape.”
Liverpool have no known fresh injury worries to contend with ahead of tonight’s north-west derby clash.
Predicted Liverpool XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Keita, Fabinho, Thiago; Salah, Jota, Mane.